News & Events
May 11, 2021
Prometheus Laboratories Announces Multiple Presentations on Precision-Guided Dosing and Monitoring at the Digestive Disease Week 2021 Annual Meeting
SAN DIEGO, May 11, 2021 / PRNewswire/ Prometheus Laboratories, Inc. (“Prometheus”), a leader of precision healthcare, announced today multiple presentations and posters on precision-guided dosing and monitoring of Inflammatory Bowel Disease (IBD) at the virtual 2021 Digestive Disease Week (DDW) meeting, being held May 21-23. Along with clinical collaborators, Prometheus will present two oral presentations, one during a plenary session; and five posters, two named as Posters of Distinction.
“The data presented at DDW this year represents our commitment to advancing precision-guided clinical testing to optimize individual treatment outcomes,” commented Dr. Thierry Dervieux, Chief Scientific Officer. “It also underscores the value of our unparalleled biorepository and database in contributing to the development and validation of novel diagnostic solutions to improve patient outcomes.”
The data presented at DDW will include:
- A model-informed precision dosing tool for adalimumab which was developed and evaluated utilizing Prometheus Anser® testing on a clinical cohort of 7,755 IBD patients. Results point to the potential use of such a model to help improve dose optimization; and
- Results from a study evaluating the combination of serum infliximab levels and an endoscopic healing index score with two Prometheus services, Anser and Monitr™, in patients with Crohn’s Disease (CD) to guide dose optimization. The data indicates the potential to allow clinicians to distinguish pharmacokinetic from pharmacodynamic failure, and thus guide therapeutic decision-making in patients with CD.
Presentations and posters highlighting data from Prometheus Lab at DDW 2021 are below:
| Abstract | Title | Date/Time/Session |
| Oral Presentation | ||
| Plenary session 780 |
HOST SEROREACTIVITY TO MICROBIAL ANTIGENS IS ASSOCIATED WITH FUTURE ONSET OF CROHN’S DISEASE INDEPENDENT OF GUT BARRIER FUNCTION, SUBCLINICAL INFLAMMATION, AND GENETIC RISK |
Sunday, May 23, 2021 from 3:30 PM to 5:00 PM EDT Immunology, Microbiology & Inflammatory Bowel Diseases (IMIBD) Section Distinguished Abstract Plenary |
| Lecture Presentation 854 |
RISK OF IMMUNOGENICITY TO A SUBSEQUENT THERAPY IS THE HIGHEST DURING THE FIRST YEAR AFTER A SWITCH IN THERAPY IN IMMUNOGENIC PATIENTS WITH INFLAMMATORY BOWEL DISEASE |
Sunday, May 23, 2021 from 5:30 PM to 7:00 PM EDT Biologic and Disease Monitoring in IBD |
| Posters | ||
| Poster of Distinction Su432 |
IMPACT OF THIOPURINE EXPOSURE ON IMMUNOGENICITY TO INFLIXIMAB IS NEGLIGIBLE IN THE SETTING OF ELEVATED INFLIXIMAB CONCENTRATIONS |
Sunday, May 23, 2021 from 12:15 PM to 1:00 PM EDT Therapeutic Monitoring |
| Poster of Distinction Su457 |
DOES PREOPERATIVE SERUM USTEKINUMAB CONCENTRATION PREDICT THIRTY-DAY POSTOPERATIVE OUTCOMES IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE UNDERGOING ABDOMINAL SURGERY? |
Sunday, May 23, 2021 from 12:15 PM to 1:00 PM EDT Immunology‚ Microbiology & Inflammatory Bowel Diseases: IBD: Uncontrolled Therapeutic Observations in Humans Biologic |
| Su444 | MODEL INFORMED PRECISION DOSING OF ADALIMUMAB BY INDIVIDUALIZED PHARMACOKINETICS IN A LARGE COHORT OF PATIENTS WITH INFLAMMATORY BOWEL DISEASES | Sunday, May 23, 2021 from 12:15 PM to 1:00 PM EDT Therapeutic Monitoring |
| Su469 | TUMOR NECROSIS FACTOR IMPACTS INFLIXIMAB CLEARANCE IN INFLAMMATORY BOWEL DISEASES | Sunday, May 23, 2021 from 12:15 PM to 1:00 PM EDT Uncontrolled Therapeutic Observations in Humans Biologic |
| Su439 | THE VALUE OF COMBINED SERUM INFLIXIMAB AND ENDOSCOPIC HEALING INDEX MONITORING FOR GUIDING INFLIXIMAB DOSING IN PATIENTS WITH CROHN’S DISEASE | Sunday, May 23, 2021 from 12:15 PM to 1:00 PM EDT Therapeutic Monitoring |
The complete abstracts can be found on the DDW 2021 website.
About Prometheus Laboratories
Prometheus Laboratories is a specialty clinical laboratory, which enables precision-guided care in Inflammatory Bowel Disease and other GI disorders. We discover, develop and commercialize testing services that help clinicians improve outcomes across the patient journey, from disease interception and stratification, to therapy selection, optimization and monitoring. For more information, please visit https://prometheuslabs.com, visit our virtual booth at DDW 2021, or engage with us on LinkedIn.
About Anser
Anser testing uniquely measures serum drug (infliximab or infliximab biosimilars, adalimumab, ustekinumab, vedolizumab) and antidrug antibody levels using a proprietary, drug tolerant, homogenous mobility shift assay technology. Anser testing aids in the assessment and optimization of biologic therapy management decisions.
About Monitr
Monitr is a first-of-its-kind, non-invasive, multi-protein serum biomarker test developed and validated to assess endoscopic disease activity in patients with CD. The test aids in distinguishing CD patients in endoscopic remission from those with active disease, providing an endoscopic healing index for objective evaluation of mucosal healing.
Investor and Media Contact
marketing@prometheuslabs.com
SOURCE Prometheus Laboratories, Inc.